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Network based statistical analysis detects changes induced by continuous theta-burst stimulation on brain activity at rest

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posted on 2023-06-08, 21:09 authored by Chiara Mastropasqua, Marco Bozzali, Viviana Ponzo, Giovanni Giulietti, Carlo Caltagirone, Mara Cercignani, Giacomo Koch
We combined continuous theta-burst stimulation (cTBS) and resting state (RS)-fMRI approaches to investigate changes in functional connectivity (FC) induced by right dorsolateral prefrontal cortex (DLPFC)-cTBS at rest in a group of healthy subjects. Seed-based fMRI analysis revealed a specific pattern of correlation between the right prefrontal cortex and several brain regions: based on these results, we defined a 29-node network to assess changes in each network connection before and after, respectively, DLPFC-cTBS and sham sessions. A decrease of correlation between the right prefrontal cortex and right parietal cortex (Brodmann areas 46 and 40, respectively) was detected after cTBS, while no significant result was found when analyzing sham-session data. To our knowledge, this is the first study that demonstrates within-subject changes in FC induced by cTBS applied on prefrontal area. The possibility to induce selective changes in a specific region without interfering with functionally correlated area could have several implications for the study of functional properties of the brain, and for the emerging therapeutic strategies based on transcranial stimulation.

History

Publication status

  • Published

File Version

  • Published version

Journal

Frontiers in Psychiatry

ISSN

1664-0640

Publisher

Frontiers Media

Issue

97

Volume

5

Page range

1-7

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-11-27

First Open Access (FOA) Date

2015-11-27

First Compliant Deposit (FCD) Date

2015-11-27

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