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LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome
journal contribution
posted on 2023-06-08, 21:28 authored by Justin Stebbing, Aleksandra Filipovic, Ian O Ellis, Andrew R Green, Tanya Rapoz D'Silva, Heinz-Josef Lenz, R Charles Coombes, Tingting Wang, Soo-Chin Lee, Georgios GiamasGeorgios GiamasInteractions between kinases and the estrogen receptor a (ERa) are thought to be a critical signaling pathway in the majority of human breast cancers. We have recently identified a previously uncharacterized molecule, lemur tyrosine kinase-3 (LMTK3) as a prognostic and predictive oncogenic ERa regulator with a central role in endocrine resistance. Unusually this protein has undergone Darwinian positive selection between Chimpanzees and humans suggesting it may contribute to human susceptibility to ERa-positive tumors. Using over 600 European primary breast cancer cases, we wished to establish tumor characteristics associated with both cytoplasmic and nuclear LMTK3 expression, and then externally validate our observed European clinical outcomes with samples from Asian individuals receiving chemotherapy. Both nuclear and cytoplasmic expression correlated with tumor grade (P < 0.001) and in the Asian cohort, independent blinded analyses demonstrated that high basal LMTK3 expression was associated with advanced stage of primary breast cancers as well as decreased overall (P = 0.03) and disease-free survival (P = 0.006). In summary, higher LMTK3 expression is associated with more aggressive cancers. These data support our previous findings and suggest LMTK3 expression may be a reliable new biomarker in breast cancer.
History
Publication status
- Published
Journal
Breast Cancer Research and TreatmentISSN
0167-6806Publisher
SpringerExternal DOI
Issue
2Volume
132Page range
537-544Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-07Usage metrics
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