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AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications
journal contribution
posted on 2023-06-08, 21:49 authored by Simon E Ward, Lewis E Pennicott, Paul BeswickThe role of glutamate and its receptors in central nervous system biology and disease has long been of interest to scientists involved in both fundamental research and drug discovery, however the complex pharmacology and lack of highly selective compounds has severely hampered drug discovery efforts in this area. Recent advances in the identification and profiling of positive allosteric modulators of the AMPA receptor offer a potential way forward and the hope of a new treatment for schizophrenia. This article will review recent patent applications published in this area.
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Publication status
- Published
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- Published version
Journal
Future Medicinal ChemistryISSN
1756-8919Publisher
Future ScienceExternal DOI
Issue
4Volume
7Page range
473-491Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-21First Compliant Deposit (FCD) Date
2015-07-21Usage metrics
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