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Are the effects of APOE ?4 on cognitive function in nonclinical populations age- and gender-dependent?

journal contribution
posted on 2023-06-08, 21:49 authored by Jennifer Rusted, Roxanna O Carare
APOE ?4 - one of three possible allelic variants (?2, ?3 and ?4) of the polymorphic protein APOE - is well characterized in its role as the strongest risk factor (after old age) for sporadic Alzheimer's disease (AD). Perhaps less well known, and certainly less well characterized, is that this ?4 variant of the APOE gene also is a significant risk factor for age-related cognitive decline in nonclinical populations. This article considers APOE ?4 effects on cognition in people without dementia, the extent to which such effects may depend on age and on gender and other interactive biological systems that change across the lifespan.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neurodegenerative Disease Management

ISSN

1758-2024

Publisher

Future Medicine

Issue

1

Volume

5

Page range

37-48

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-07-22

First Compliant Deposit (FCD) Date

2015-07-22

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