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Are the effects of APOE ?4 on cognitive function in nonclinical populations age- and gender-dependent?
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posted on 2023-06-08, 21:49 authored by Jennifer Rusted, Roxanna O CarareAPOE ?4 - one of three possible allelic variants (?2, ?3 and ?4) of the polymorphic protein APOE - is well characterized in its role as the strongest risk factor (after old age) for sporadic Alzheimer's disease (AD). Perhaps less well known, and certainly less well characterized, is that this ?4 variant of the APOE gene also is a significant risk factor for age-related cognitive decline in nonclinical populations. This article considers APOE ?4 effects on cognition in people without dementia, the extent to which such effects may depend on age and on gender and other interactive biological systems that change across the lifespan.
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- Published
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- Published version
Journal
Neurodegenerative Disease ManagementISSN
1758-2024Publisher
Future MedicineExternal DOI
Issue
1Volume
5Page range
37-48Department affiliated with
- Psychology Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-22First Compliant Deposit (FCD) Date
2015-07-22Usage metrics
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