Jenkins, Valerie, Fallowfield, Lesley, Langridge, Carolyn, Barrett, Jessica, Ryan, Andy, Jacobs, Ian, Kilkerr, Justine, Menon, Usha and Farewell, Vernon (2015) Psychosocial factors associated with withdrawal from the United Kingdom collaborative trial of ovarian cancer screening after 1 episode of repeat screening. International Journal Of Gynecological Cancer, 25 (8). pp. 1519-1525. ISSN 1048-891X

Preview

PDF - Accepted Version Download (312kB) | Preview

Abstract

Objective: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of 2 different ovarian cancer screening schedules. The psychosocial substudy examines the psychological factors associated with the screening program.

Methods: Women aged 50 to 75 years from 16 UK gynecologic centers randomized to annual multimodal screening or ultrasound screening (US) groups were followed up for 7 years. Psychosocial data from women who withdrew from the study after a repeat screen were examined.

Results: Sixteen percent (3499/21,733) of women requiring a repeat screening test in addition to annual screen withdrew from the study: 12.9% (1560/12,073) from the multimodal group and 20.1% (1939/9660) from the US group. An estimated relative risk of withdrawal is 1.46 (95% confidence interval, 1.36-1.56; P <= 0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal, even when age, screening center, and group were taken into account (P < 0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year.

Conclusions: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety, and above threshold general psychological morbidity all increased the withdrawal rate.

Item Type:	Article
Keywords:	Ovarian cancer; population screening programme; withdrawal; anxiety; psychological morbidity; UKCTOCS
Schools and Departments:	Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C)
Subjects:	R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Depositing User:	Kathryn Monson
Date Deposited:	22 Jul 2015 14:21
Last Modified:	15 Mar 2017 03:20
URI:	http://srodev.sussex.ac.uk/id/eprint/55675

View download statistics for this item

📧 Request an update