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Psychosocial factors associated with withdrawal from the United Kingdom collaborative trial of ovarian cancer screening after 1 episode of repeat screening
journal contribution
posted on 2023-06-08, 21:49 authored by Valerie JenkinsValerie Jenkins, Lesley FallowfieldLesley Fallowfield, Carolyn Langridge, Jessica Barrett, Andy Ryan, Ian Jacobs, Justine Kilkerr, Usha Menon, Vernon FarewellObjective: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of 2 different ovarian cancer screening schedules. The psychosocial substudy examines the psychological factors associated with the screening program. Methods: Women aged 50 to 75 years from 16 UK gynecologic centers randomized to annual multimodal screening or ultrasound screening (US) groups were followed up for 7 years. Psychosocial data from women who withdrew from the study after a repeat screen were examined. Results: Sixteen percent (3499/21,733) of women requiring a repeat screening test in addition to annual screen withdrew from the study: 12.9% (1560/12,073) from the multimodal group and 20.1% (1939/9660) from the US group. An estimated relative risk of withdrawal is 1.46 (95% confidence interval, 1.36-1.56; P <= 0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal, even when age, screening center, and group were taken into account (P < 0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year. Conclusions: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety, and above threshold general psychological morbidity all increased the withdrawal rate.
Funding
UKCTOCS; RQ01-G0543; Medical Research Council; G9901012
Eve Appeal Foundation
History
Publication status
- Published
File Version
- Accepted version
Journal
International Journal Of Gynecological CancerISSN
1048-891XPublisher
Lippincott, Williams & WilkinsExternal DOI
Issue
8Volume
25Page range
1519-1525Department affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-22First Open Access (FOA) Date
2016-09-01First Compliant Deposit (FCD) Date
2015-07-22Usage metrics
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