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Increased intraindividual reaction time variability in persons with neuropsychiatric manifestations of systemic lupus erythematosus
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posted on 2023-06-08, 21:50 authored by Becky I Haynes, David Bunce, Kevin DaviesKevin Davies, Jennifer RustedSystemic Lupus Erythematosus (SLE) can affect multiple organ systems, including the central (CNS) and/or peripheral nervous system. Individuals with nervous system involvement (termed Neuropsychiatric SLE or NPSLE) can present with nonspecific symptoms such as cognitive dysfunction. It is difficult to ascertain whether this is a direct consequence of lupus disease activity on the brain. Intraindividual variability, measured through trial-to-trial reaction time variation, has been proposed as a behavioral marker of CNS integrity. We compared 14 NPSLE, 20 non-NPSLE, and 27 age-matched healthy participants using multiple variability metrics. Variability was increased in NPSLE compared with non-NPSLE participants, and was increased throughout the distribution rather than there being a selective increase in extreme reaction times. Variability metrics were strongly intercorrelated providing convergent evidence that the different metrics are tapping similar processes. The results suggest that there is ongoing disruption to cognitive processing in NPSLE and may indicate small fluctuations in attention.
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Publication status
- Published
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- Published version
Journal
Archives of Clinical NeuropsychologyISSN
1873-5843Publisher
Oxford University PressExternal DOI
Issue
3Volume
30Page range
271-9Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-23First Compliant Deposit (FCD) Date
2015-07-23Usage metrics
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