The route of glucose to the brain from food in the mouth of the rat

Pilcher, C W, Jarman, S P and Booth, David A (1974) The route of glucose to the brain from food in the mouth of the rat. Journal of Comparative and Physiological Psychology, 87 (1). pp. 56-61. ISSN 0021-9940

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Conducted an experiment with 28 male albino Sprague- Dawley rats. It was found that when dextroglucose-C14 was placed in the oropharyngeal cavity of anesthetized Ss with the esophagus ligated, generally no radioactivity was detectable in the brain (or liver) after 5 or 10 min. When Ss were allowed to drink radioactive starch or were stomach-tubed radioactive glucose, .2-1.3% of the radioactivity was recovered in the brain after 5 min. The medial diencephalon had a high-uptake rate but was not unique in that respect. It is concluded that if there is a "direct" (transbuccal) route to the brain, it is negligible compared with the well-known intestinal route. Also, on an empty stomach at least, an initial sample of glucose from food starch can reach the brain within a few minutes from the start of a meal.

Item Type: Article
Additional Information: The reported experiments were run in the Laboratory of Experimental Psychology, School of Biological Sciences, University of Sussex in 1972.
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QP Physiology > QP0001 General Including influence of the environment > QP0136 Appetite
Q Science > QP Physiology > QP0501 Animal biochemistry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: prof. David Booth
Date Deposited: 01 Sep 2015 13:08
Last Modified: 01 Sep 2015 13:08
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