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Low dose response for 2 deoxy D glucose induced feeding and the involvement of peripheral factors
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posted on 2023-06-08, 22:18 authored by R G Jones, D A BoothLatencies to feed and meal sizes were observed in recently satiated rats injected intraperitoneally with an isotonic solution of 2-deoxyglucose, using 3-O-methyl glucose for the control injection. The feeding response latency shortened monotonically with dose from about 0.3 mmole/kg (50 mg/kg) to 0.5–0.6 mmole/kg, with an extended plateau up to debilitating doses. At modest doses, the latency to feed was shorter in adrenal demedullated rats than in intact rats, suggesting that the hyperglycemic response to 2DG partially inhibits the feeding response. Food-deprived rats took larger meals following 2DG injection, if there had been recent rapid intestinal absorption of glucose. It is suggested that a major action of 2DG is to block the satiating consequences of the process of absorption, possibly at hepatic receptors.
History
Publication status
- Published
Journal
Physiology and BehaviorISSN
0031-9384Publisher
ElsevierExternal DOI
Issue
1Volume
15Page range
85-90Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-01Usage metrics
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