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A switch in the mode of the sodium/calcium exchanger underlies an age-related increase in the slow afterhyperpolarization

journal contribution
posted on 2023-06-08, 22:26 authored by Greg Scutt, Marcus Allen, George KemenesGeorge Kemenes, Mark Yeoman
During aging, the Ca(2+)-sensitive slow afterhyperpolarization (sAHP) of hippocampal neurons is known to increase in duration. This change has also been observed in the serotonergic cerebral giant cells (CGCs) of the pond snail Lymnaea stagnalis, but has yet to be characterized. In this article, we confirm that there is a reduction in firing rate, an increase in the duration of the sAHP, and an alteration in the strength and speed of spike frequency adaptation in the CGCs during aging, a finding that is compatible with an increase in the sAHP current. We go on to show that age-related changes in the kinetics of spike frequency adaptation are consistent with a reduction in Ca(2+) clearance from the cell, which we confirm with Ca(2+) imaging and pharmacological manipulation of the sodium calcium exchanger. These experiments suggest that the sodium calcium exchanger may be switching to a reverse-mode configuration in the CGCs during aging.

Funding

Decision Making in Neural Networks: Influence of Learning; G0189; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/H009906/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Neurobiology of aging

ISSN

1558-1497

Publisher

Elsevier

Issue

10

Volume

36

Page range

2838-2849

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-09-10

First Compliant Deposit (FCD) Date

2015-09-10

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