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The role of PARPs in DNA strand break repair

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posted on 2023-06-08, 22:34 authored by Stuart L Rulten, Francoise Dantzer, Keith CaldecottKeith Caldecott
ADP-ribosylation is a post-translational modification in which a target protein becomes modified with monomeric, short chains, or long branching chains of ADP-ribose (ADPR). The process can be carried out by a number of ADP-ribosyltransferases and polymerases (ADP-RTs and PARPs) and the consequences of ribosylation are as diverse and heterogeneous as the products that are formed. In mammalian cells, only three PARPs bind to DNA, and their activity is stimulated by DNA ends. A number of roles for these three PARPs have been characterised, including several functions in DNA repair. The known repertoire of ADPR-binding proteins is vastly expanding, meaning that ribosylation increases the rate and complexity of ways in which DNA is repaired by a number of different ways.

History

Publication status

  • Published

ISSN

2196-9906

Publisher

Humana Press

Volume

83

Page range

47-78

Pages

591.0

Book title

PARP Inhibitors for Cancer Therapy

Place of publication

New York

ISBN

9783319141503

Series

Cancer Drug Discovery and Development

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Editors

Ricky A Sharma, Nicola J Curtin

Legacy Posted Date

2015-09-18

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