File(s) not publicly available
Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens
journal contribution
posted on 2023-06-08, 22:36 authored by Stefano Caserta, Jessica Geraldine Borger, Rose ZamoyskaHarnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.
History
Publication status
- Published
Journal
Critical Reviews in ImmunologyISSN
1040-8401Publisher
Begell HouseExternal DOI
Issue
2Volume
32Page range
97-126Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-30Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC