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Caserta, Stefano, Borger, Jessica Geraldine and Zamoyska, Rose (2012) Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical Reviews in Immunology, 32 (2). pp. 97-126. ISSN 1040-8401
Full text not available from this repository.Abstract
Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.
| Item Type: | Article |
|---|---|
| Keywords: | T cell biology; tumour immunology; immunotherapy |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Global Health and Infection |
| Subjects: | Q Science > QR Microbiology > QR0180 Immunology R Medicine > RM Therapeutics. Pharmacology > RM0270 Immunotherapy. Serotherapy |
| Depositing User: | Stefano Caserta |
| Date Deposited: | 30 Sep 2015 06:48 |
| Last Modified: | 21 Sep 2017 13:52 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/56872 |