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miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

journal contribution
posted on 2023-06-08, 22:41 authored by Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew PennAndrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine, Alexandre Favereaux
We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3' untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Neuroscience

ISSN

1097-6256

Publisher

Nature Publishing Group

Issue

8

Volume

17

Page range

1040-1042

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-10-07

First Compliant Deposit (FCD) Date

2021-03-09

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