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miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling
journal contribution
posted on 2023-06-08, 22:41 authored by Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew PennAndrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine, Alexandre FavereauxWe investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3' untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.
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- Published
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- Published version
Journal
Nature NeuroscienceISSN
1097-6256Publisher
Nature Publishing GroupExternal DOI
Issue
8Volume
17Page range
1040-1042Department affiliated with
- Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-10-07First Compliant Deposit (FCD) Date
2021-03-09Usage metrics
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