University of Sussex
Browse

File(s) not publicly available

Cytokine and growth factor profiling in patients with the metabolic syndrome

journal contribution
posted on 2023-06-08, 22:55 authored by Seyed Reza Mirhafez, Alireza Pasdar, Amir Avan, Habibollah Esmaily, Atefeh Moezzi, Mohsen Mohebati, Zahra Meshkat, Hassan Mehrad-Majd, Saied Eslami, Hamid Reza Rahimi, Hamed Ghazavi, Gordon FernsGordon Ferns, Majid Ghayour-Mobarhan
The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38-55 v. 82-18 pg/ml; P<0-05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention. Copyright © The Authors 2015.

History

Publication status

  • Published

Journal

British Journal of Nutrition

ISSN

0007-1145

Publisher

Cambridge University Press

Issue

12

Volume

113

Page range

1911-1919

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-10-26

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC