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The role of setting for ketamine abuse: clinical and preclinical evidence
journal contribution
posted on 2023-06-08, 22:58 authored by Maria Teresa De Luca, Maria Meringolo, Primavera Alessandra Spagnolo, Aldo BadianiDrug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug. This is particularly evident in the case of 'club drugs', such as ketamine. Although the number of ketamine abusers is relatively small in the general population, it is quite substantial in some settings. In particular, ketamine abuse is almost exclusively limited to clubs and large music parties, which suggests a major role of context in modulating the reward effects of this drug. This review focuses on recent preclinical and clinical findings, including previously unpublished data, that provide evidence that, even under controlled conditions, ketamine reward is a function of the setting of drug taking.
History
Publication status
- Published
File Version
- Published version
Journal
Reviews in the neurosciencesISSN
0334-1763Publisher
De GruyterExternal DOI
Issue
5-6Volume
23Page range
769-780Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-10-28First Open Access (FOA) Date
2015-10-28First Compliant Deposit (FCD) Date
2015-10-28Usage metrics
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