University of Sussex
Browse
cmmm15.pdf (3.2 MB)

Time-delayed models of gene regulatory networks

Download (3.2 MB)
journal contribution
posted on 2023-06-08, 22:58 authored by K Parmar, Konstantin BlyussKonstantin Blyuss, Yuliya KyrychkoYuliya Kyrychko, S J Hogan
We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.

History

Publication status

  • Published

File Version

  • Published version

Journal

Computational and Mathematical Methods in Medicine

ISSN

1748-6718

Publisher

Hindawi

Volume

2015

Department affiliated with

  • Mathematics Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-10-29

First Open Access (FOA) Date

2015-10-29

First Compliant Deposit (FCD) Date

2015-10-28

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC