Time-delayed models of gene regulatory networks

Parmar, K, Blyuss, K B, Kyrychko, Y N and Hogan, S J (2015) Time-delayed models of gene regulatory networks. Computational and Mathematical Methods in Medicine, 2015. ISSN 1748-6718

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We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science > QA Mathematics
Depositing User: Konstantin Blyuss
Date Deposited: 29 Oct 2015 12:27
Last Modified: 07 Mar 2017 06:19
URI: http://srodev.sussex.ac.uk/id/eprint/57395

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