Greger, Ingo H, Ziff, Edward B and Penn, Andrew C (2007) Molecular determinants of AMPA receptor subunit assembly. Trends in Neurosciences, 30 (8). pp. 407-416. ISSN 0166-2236
Full text not available from this repository.Abstract
AMPA-type (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) glutamate receptors (AMPARs) mediate post-synaptic depolarization and fast excitatory transmission in the central nervous system. AMPARs are tetrameric ion channels that assemble in the endoplasmic reticulum (ER) in a poorly understood process. The subunit composition determines channel conductance properties and gating kinetics, and also regulates vesicular traffic to and from synaptic sites, and is thus critical for synaptic function and plasticity. The distribution of functionally different AMPARs varies within and between neuronal circuits, and even within individual neurons. In addition, synapses employ channels with specific subunit stoichiometries, depending on the type of input and the frequency of stimulation. Taken together, it appears that assembly is not simply a stochastic process. Recently, progress has been made in understanding the molecular mechanisms underlying subunit assembly and receptor biogenesis in the ER. These processes ultimately determine the size and shape of the postsynaptic response, and are the subject of this review.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Neuroscience |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry |
Depositing User: | Stephanie Turley |
Date Deposited: | 03 Dec 2015 12:24 |
Last Modified: | 03 Dec 2015 12:24 |
URI: | http://srodev.sussex.ac.uk/id/eprint/58606 |