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Mechanisms of regulation of mature miRNAs

journal contribution
posted on 2023-06-08, 23:56 authored by Benjamin P Towler, Chris JonesChris Jones, Sarah NewburySarah Newbury
MicroRNAs (miRNAs) are short RNA molecules of around 22nt in length that play important roles in post-transcriptional control of gene expression. miRNAs normally function as negative regulators of mRNA expression by binding complementary sequences in the 3’ UTR of target mRNAs and causing translational repression and/or target degradation. Much research has been undertaken to enhance understanding of the biogenesis, function and targeting of miRNAs. However, until recently, the mechanisms underlying the regulation of the levels of mature miRNAs themselves have been largely overlooked. Although it has generally been assumed that miRNAs are stable molecules, recent evidence indicates that the stability of specific mature miRNAs can be regulated during key cellular and developmental processes in certain cell types. Here we discuss the current knowledge of the mechanisms by which mature miRNAs are regulated in the cell and the factors that contribute to the control of their stability.

Funding

Studentship-Towler; WC003-11; BSMS; WC003-11

Epigenetic regulation of gene expression by the exoribonuclease pacman; G0056; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/I021345/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Issue

6

Volume

43

Page range

1208-1214

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-11

First Compliant Deposit (FCD) Date

2016-01-11

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