DNA repair, genome stability and cancer: a historical perspective

Jeggo, Penny A, Pearl, Laurence H and Carr, Antony M (2016) DNA repair, genome stability and cancer: a historical perspective. Nature Reviews Cancer, 16 (1). pp. 35-42. ISSN 1474-1768

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The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Laurence Pearl
Date Deposited: 15 Jan 2016 10:52
Last Modified: 15 Jan 2016 10:52
URI: http://srodev.sussex.ac.uk/id/eprint/59213
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