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DNA repair, genome stability and cancer: a historical perspective
journal contribution
posted on 2023-06-09, 00:03 authored by Penny Jeggo, Laurence PearlLaurence Pearl, Antony CarrAntony CarrThe multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.
History
Publication status
- Published
File Version
- Accepted version
Journal
Nature Reviews CancerISSN
1474-175XPublisher
Nature Publishing GroupExternal DOI
Issue
1Volume
16Page range
35-42Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-18First Open Access (FOA) Date
2016-08-01First Compliant Deposit (FCD) Date
2016-01-18Usage metrics
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