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A review of hot-melt extrusion: process technology to pharmaceutical products

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journal contribution
posted on 2023-06-09, 00:11 authored by Mohammed Maniruzzaman, Joshua S Boateng, Martin J Snowden, Dennis Douroumis
Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.

History

Publication status

  • Published

File Version

  • Published version

Journal

ISRN Pharmaceutics

ISSN

2090-6153

Publisher

Hindawi Publishing Corporation

Issue

436763

Volume

2012

Page range

1-9

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-29

First Open Access (FOA) Date

2016-01-29

First Compliant Deposit (FCD) Date

2016-01-29

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