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A review of hot-melt extrusion: process technology to pharmaceutical products
journal contribution
posted on 2023-06-09, 00:11 authored by Mohammed Maniruzzaman, Joshua S Boateng, Martin J Snowden, Dennis DouroumisOver the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.
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Publication status
- Published
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- Published version
Journal
ISRN PharmaceuticsISSN
2090-6153Publisher
Hindawi Publishing CorporationExternal DOI
Issue
436763Volume
2012Page range
1-9Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-29First Open Access (FOA) Date
2016-01-29First Compliant Deposit (FCD) Date
2016-01-29Usage metrics
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