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Ferrati Martini Maravall front neural circuits 2016.pdf (699.47 kB)

Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway

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posted on 2023-06-09, 00:22 authored by Giovanni Ferrati, Francisco J Martini, Miguel Maravall RodriguezMiguel Maravall Rodriguez
Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In “driver” thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC connections onto layer 4 neurons in mouse barrel cortex express variable STP. Each synapse responds to input trains with a distinct pattern of depression or facilitation around its mean steady-state response. As a result, in common with other synaptic populations, lemniscal TC synapses express diverse rather than uniform dynamics, allowing for a rich representation of temporally varying stimuli. Here, we show that this STP diversity is regulated presynaptically. Presynaptic adenosine receptors of the A1R type, but not kainate receptors (KARs), modulate STP behavior. Blocking the receptors does not eliminate diversity, indicating that diversity is related to heterogeneous expression of multiple mechanisms in the pathway from presynaptic calcium influx to neurotransmitter release.

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Publication status

  • Published

File Version

  • Published version

Journal

Frontiers in Neural Circuits

ISSN

1662-5110

Publisher

Frontiers Media

Volume

10

Page range

9

Department affiliated with

  • Neuroscience Publications

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This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-02-23

First Open Access (FOA) Date

2016-02-23

First Compliant Deposit (FCD) Date

2016-02-23

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