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Prediction of primary somatosensory neuron activity during active tactile exploration
journal contribution
posted on 2023-06-09, 00:35 authored by Darlo Campagner, Mathew Hywel Evans, Michael Bale, Andrew Erskine, Rasmus Strange PetersenPrimary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimotor integration, we recorded from primary mechanosensory neurons of awake, head-fixed mice as they explored a pole with their whiskers, and simultaneously measured both whisker motion and forces with high-speed videography. Using Generalised Linear Models, we found that primary neuron responses were poorly predicted by whisker angle, but well-predicted by rotational forces acting on the whisker: both during touch and free-air whisker motion. These results are in apparent contrast to previous studies of passive stimulation, but could be reconciled by differences in the kinematics-force relationship between active and passive conditions. Thus, simple statistical models can predict rich neural activity elicited by natural, exploratory behaviour involving active movement of sense organs.
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- Published
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- Published version
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eLIFEISSN
2050-084XPublisher
eLife Sciences PublicationsExternal DOI
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5Department affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-03-15First Open Access (FOA) Date
2016-03-15First Compliant Deposit (FCD) Date
2016-03-15Usage metrics
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