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Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates
journal contribution
posted on 2023-06-09, 00:39 authored by Mark BagleyMark Bagley, Ayed Alnomsy, Scott J TempleMicrowave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 h facilitated Bohlmann-Rahtz pyridine synthesis to give highly-substituted ethyl 2 aminonicotinates with total regiocontrol and in reasonable to excellent yield, following purification by immobiliza tion upon an acidic resin.
Funding
Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate (Strathclyde lead); G0926; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; RKES 115428
PhD Studentship; 21216348; Saudi Cultural Bureau; i532
Medicinal chemistry and drug discovery centre; BS450-93; R M Phillips Trust
History
Publication status
- Published
File Version
- Accepted version
Journal
SYNLETTISSN
0936-5214Publisher
Thieme PublishingExternal DOI
Issue
11Volume
27Page range
1728-1732Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-03-30First Open Access (FOA) Date
2017-07-01First Compliant Deposit (FCD) Date
2016-03-23Usage metrics
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