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Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates

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posted on 2023-06-09, 00:39 authored by Mark BagleyMark Bagley, Ayed Alnomsy, Scott J Temple
Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 h facilitated Bohlmann-Rahtz pyridine synthesis to give highly-substituted ethyl 2 aminonicotinates with total regiocontrol and in reasonable to excellent yield, following purification by immobiliza tion upon an acidic resin.

Funding

Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate (Strathclyde lead); G0926; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; RKES 115428

PhD Studentship; 21216348; Saudi Cultural Bureau; i532

Medicinal chemistry and drug discovery centre; BS450-93; R M Phillips Trust

History

Publication status

  • Published

File Version

  • Accepted version

Journal

SYNLETT

ISSN

0936-5214

Publisher

Thieme Publishing

Issue

11

Volume

27

Page range

1728-1732

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-03-30

First Open Access (FOA) Date

2017-07-01

First Compliant Deposit (FCD) Date

2016-03-23

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