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Depression phenotype, inflammation and the brain: implications for future research

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posted on 2023-06-09, 00:45 authored by Rajeev Krishnadas, Neil Harrison
Inflammation is implicated in the etiology of Major Depressive Disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation and cognition and its relationship to MDD. In this issue, Byrne and colleagues report the first systematic review of these studies. The systematic review provides a much-needed synthesis of current research findings and highlights the role of cortical and subcortical brain structure and function. In this accompanying commentary, we highlight further points of particular relevance to future studies, including the potential advantages of functional phenotype models rather than the emphasis on mutually exclusive diagnostic categories in describing MDD and other psychiatric disorders. Novel imaging techniques will further enhance possibilities to clarify the link between inflammation and depression. New research challenges are described regarding the relationships between behavioural phenotype, brain structure and function, and peripheral inflammation.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Psychosomatic Medicine

ISSN

0033-3174

Publisher

Lippincott, Williams & Wilkins

Issue

4

Volume

78

Page range

384-388

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-04-04

First Open Access (FOA) Date

2017-05-01

First Compliant Deposit (FCD) Date

2016-04-04

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