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Differential neural mechanisms for early and late prediction error detection

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posted on 2023-06-09, 00:48 authored by Rahim Malekshahi, Anil SethAnil Seth, Amalia Papanikolaou, Zenon Mathews, Niels Birbaumer, Paul F M J Verschure, Andrea Caria
Emerging evidence indicates that prediction, instantiated at different perceptual levels, facilitate visual processing and enable prompt and appropriate reactions. Until now, the mechanisms underlying the effect of predictive coding at different stages of visual processing have still remained unclear. Here, we aimed to investigate early and late processing of spatial prediction violation by performing combined recordings of saccadic eye movements and fast event-related fMRI during a continuous visual detection task. Psychophysical reverse correlation analysis revealed that the degree of mismatch between current perceptual input and prior expectations is mainly processed at late rather than early stage, which is instead responsible for fast but general prediction error detection. Furthermore, our results suggest that conscious late detection of deviant stimuli is elicited by the assessment of prediction error’s extent more than by prediction error per se. Functional MRI and functional connectivity data analyses indicated that higher-level brain systems interactions modulate conscious detection of prediction error through top-down processes for the analysis of its representational content, and possibly regulate subsequent adaptation of predictivemodels. Overall, our experimental paradigm allowed to dissect explicit from implicit behavioral and neural responses to deviant stimuli in terms of their reliance on predictive models.

History

Publication status

  • Published

File Version

  • Published version

Journal

Scientific Reports

ISSN

0028-0836

Publisher

Nature Publishing Group

Volume

6

Article number

a24350

Department affiliated with

  • Informatics Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-04-07

First Open Access (FOA) Date

2017-03-02

First Compliant Deposit (FCD) Date

2016-04-06

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