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Discovery and characterization of smORF-encoded bioactive polypeptides
journal contribution
posted on 2023-06-09, 00:59 authored by Alan Saghatelian, Juan Pablo CousoAnalysis of genomes, transcriptomes and proteomes reveals the existence of hundreds to thousands of translated, yet non-annotated, short open reading frames (small ORFs or smORFs). The discovery of smORFs and their protein products, smORF-encoded polypeptides (SEPs), points to a fundamental gap in our knowledge of protein-coding genes. Various studies have identified central roles for smORFs in metabolism, apoptosis and development. The discovery of these bioactive SEPs emphasizes the functional potential of this unexplored class of biomolecules. Here, we provide an overview of this emerging field and highlight the opportunities for chemical biology to answer fundamental questions about these novel genes. Such studies will provide new insights into the protein-coding potential of genomes and identify functional genes with roles in biology and disease.
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Publication status
- Published
Journal
Nature Chemical BiologyISSN
1552-4469Publisher
Nature Publishing GroupExternal DOI
Issue
12Volume
11Page range
909-916Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
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- Yes
Legacy Posted Date
2016-04-22Usage metrics
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