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Discovery and characterization of smORF-encoded bioactive polypeptides

journal contribution
posted on 2023-06-09, 00:59 authored by Alan Saghatelian, Juan Pablo Couso
Analysis of genomes, transcriptomes and proteomes reveals the existence of hundreds to thousands of translated, yet non-annotated, short open reading frames (small ORFs or smORFs). The discovery of smORFs and their protein products, smORF-encoded polypeptides (SEPs), points to a fundamental gap in our knowledge of protein-coding genes. Various studies have identified central roles for smORFs in metabolism, apoptosis and development. The discovery of these bioactive SEPs emphasizes the functional potential of this unexplored class of biomolecules. Here, we provide an overview of this emerging field and highlight the opportunities for chemical biology to answer fundamental questions about these novel genes. Such studies will provide new insights into the protein-coding potential of genomes and identify functional genes with roles in biology and disease.

History

Publication status

  • Published

Journal

Nature Chemical Biology

ISSN

1552-4469

Publisher

Nature Publishing Group

Issue

12

Volume

11

Page range

909-916

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-04-22

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