Structural neural networks subserving oculomotor function in first-episode schizophrenia

Bagary, M S, Hutton, S B, Symms, M R, Barker, G J, Mutsatsa, S H, Barnes, T R, Joyce, E M and Ron, M A (2004) Structural neural networks subserving oculomotor function in first-episode schizophrenia. Biological Psychiatry, 56 (9). pp. 620-627. ISSN 0006-3223

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BACKGROUND: Smooth pursuit and antisaccade abnormalities are well documented in schizophrenia, but their neuropathological correlates remain unclear. METHODS: In this study, we used statistical parametric mapping to investigate the relationship between oculomotor abnormalities and brain structure in a sample of first-episode schizophrenia patients (n = 27). In addition to conventional volumetric magnetic resonance imaging, we also used magnetization transfer ratio, a technique that allows more precise tissue characterization. RESULTS: We found that smooth pursuit abnormalities were associated with reduced magnetization transfer ratio in several regions, predominantly in the right prefrontal cortex. Antisaccade errors correlated with gray matter volume in the right medial superior frontal cortex as measured by conventional magnetic resonance imaging but not with magnetization transfer ratio. CONCLUSIONS: These preliminary results demonstrate that specific structural abnormalities are associated with abnormal eye movements in schizophrenia.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Depositing User: Samuel Hutton
Date Deposited: 07 Dec 2006
Last Modified: 07 Mar 2017 09:38
Google Scholar:17 Citations

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