Ford et al 2015.pdf (1.95 MB)
Effects of Aß exposure on longterm associative memory and its neuronal mechanisms in a defined neuronal network
journal contribution
posted on 2023-06-09, 01:11 authored by Lenzie Ford, Michael CrossleyMichael Crossley, Thomas Williams, Julian R Thorpe, Louise SerpellLouise Serpell, George KemenesGeorge KemenesAmyloid beta (Aß ) induced neuronal death has been linked to memory loss, perhaps the most devastating symptom of Alzheimer’s disease (AD). Although Aß -induced impairment of synaptic or intrinsic plasticity is known to occur before any cell death, the links between these neurophysiological changes and the loss of specific types of behavioral memory are not fully understood. Here we used a behaviorally and physiologically tractable animal model to investigate Aß -induced memory loss and electrophysiological changes in the absence of neuronal death in a defined network underlying associative memory. We found similar behavioral but different neurophysiological effects for Aß 25-35 and Aß 1-42 in the feeding circuitry of the snail Lymnaea stagnalis. Importantly, we also established that both the behavioral and neuronal effects were dependent upon the animals having been classically conditioned prior to treatment, since Aß application before training caused neither memory impairment nor underlying neuronal changes over a comparable period of time following treatment.
Funding
Amyloid structure and function; MRC; MR/K022105/1
Learning and memory mechanisms; BBSRC; BB/H009906/1
History
Publication status
- Published
File Version
- Published version
Journal
Scientific ReportsISSN
2045-2322Publisher
Nature Publishing GroupExternal DOI
Volume
5Page range
10614Department affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-05-10First Open Access (FOA) Date
2016-05-10First Compliant Deposit (FCD) Date
2016-05-10Usage metrics
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