McGuigan_et_al-2016-ChemistryOpen.pdf (565.32 kB)
Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues
journal contribution
posted on 2023-06-09, 01:36 authored by Christopher McGuigan, Michaela Serpi, Magdalena Slusarczyk, Valentina Ferrari, Fabrizio Pertusati, Silvia Meneghesso, Marco Derudas, Laura Farleigh, Paola Zanetta, Joachim BugertA series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5'-O-tritylated and the 5'-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5'O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at µm concentrations, however significantly weaker potency against YFV.
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Publication status
- Published
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- Published version
Journal
ChemistryOpenISSN
2191-1363Publisher
Wiley Open AccessExternal DOI
Issue
5Volume
2016Page range
227-235Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-09-09First Open Access (FOA) Date
2016-09-09First Compliant Deposit (FCD) Date
2016-09-09Usage metrics
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