File(s) under permanent embargo
Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory
journal contribution
posted on 2023-06-09, 01:37 authored by Huimin Wan, E C Warburton, X O Zhu, T J Koder, Y Park, J P Aggleton, K Cho, Z I Bashir, M W BrownBenzodiazepines, including lorazepam, are widely used in human medicine as anxiolytics or sedatives, and at higher doses can produce amnesia. Here we demonstrate that in rats lorazepam impairs both recognition memory and synaptic plastic processes (long-term depression and long-term potentiation). Both impairments are produced by actions in perirhinal cortex. The findings thus establish a mechanism by means of which benzodiazepines impair recognition memory. The findings also strengthen the hypotheses that the familiarity discrimination component of recognition memory is dependent on reductions in perirhinal neuronal responses when stimuli are repeated and that these response reductions are due to a plastic mechanism also used in long-term depression.
History
Publication status
- Published
File Version
- Published version
Journal
European Journal of NeuroscienceISSN
0953-816XPublisher
WileyExternal DOI
Issue
8Volume
20Page range
2214-2224Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-04-07First Compliant Deposit (FCD) Date
2017-04-06Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC