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Regioselective routes to orthogonally-substituted aromatic MIDA boronates.pdf (822 kB)

Regioselective routes to orthogonally-substituted aromatic MIDA boronates

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Version 2 2023-06-12, 06:40
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journal contribution
posted on 2023-06-12, 06:40 authored by Adam J Close, Paul Kemmitt, S Mark Roe, John SpencerJohn Spencer
A series of tetrasubstituted aromatics has been synthesized, many of which are based on elaborated N-methyliminodiacetic acid (MIDA)-boronates. A sequence employing nitration, bromination, stepwise Suzuki-Miyaura (SM) coupling with a boronic acid, then base-mediated unmasking of the boronic acid from the MIDA-boronate and a second SM-coupling has led to our desired, mainly 1,2,4,5-substituted tetrasubstituted aromatic targets.

History

Publication status

  • Published

File Version

  • Published version

Journal

Organic and Biomolecular Chemistry

ISSN

1477-0520

Publisher

Royal Society of Chemistry

Issue

28

Volume

14

Page range

6751-6756

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-06-20

First Open Access (FOA) Date

2017-01-23

First Compliant Deposit (FCD) Date

2016-06-18

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