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LJFMarch30thClean Revised Perspectives for SRO.pdf (629.31 kB)

Patient-reported outcomes in metastatic castration-resistant prostate cancer

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journal contribution
posted on 2023-06-09, 02:08 authored by Lesley FallowfieldLesley Fallowfield, Heather Payne, Valerie JenkinsValerie Jenkins
Many novel therapies are available for use in patients with metastatic castration-resistant prostate cancer (mCRPC), some of which convey substantial progression-free survival and overall survival benefits. Delaying disease progression and providing palliation of symptoms are primary therapeutic aims of treating patients with mCRPC; therefore, ensuring that the benefit-to-harm ratios are acceptable to patients, through systematic measurement of patient-reported outcomes (PROs) using validated tools, is vital. In this Perspectives, we appraised the published reports from clinical trials testing treatments of mCRPC over the past 5 years and found that PROs were either not being measured routinely, or if used, were often not reported adequately, thus hampering evaluation of the true effects of many of these treatments on patients' quality of life. Improvements are needed because data collected directly from patients, not just physician-collected safety data and adverse events, are crucial to inform clinical decision-making on treatment options.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Nature Reviews Clinical Oncology

ISSN

1759-4774

Publisher

Macmillan Publishers Limited

Issue

10

Volume

13

Page range

643-650

Department affiliated with

  • Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-07-12

First Open Access (FOA) Date

2016-12-29

First Compliant Deposit (FCD) Date

2016-07-12

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