Patient-reported outcomes in metastatic castration-resistant prostate cancer

Fallowfield, Lesley, Payne, Heather and Jenkins, Valerie (2016) Patient-reported outcomes in metastatic castration-resistant prostate cancer. Nature Reviews Clinical Oncology, 13 (10). pp. 643-650. ISSN 1759-4774

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Many novel therapies are available for use in patients with metastatic castration-resistant prostate cancer (mCRPC), some of which convey substantial progression-free survival and overall survival benefits. Delaying disease progression and providing palliation of symptoms are primary therapeutic aims of treating patients with mCRPC; therefore, ensuring that the benefit-to-harm ratios are acceptable to patients, through systematic measurement of patient-reported outcomes (PROs) using validated tools, is vital. In this Perspectives, we appraised the published reports from clinical trials testing treatments of mCRPC over the past 5 years and found that PROs were either not being measured routinely, or if used, were often not reported adequately, thus hampering evaluation of the true effects of many of these treatments on patients' quality of life. Improvements are needed because data collected directly from patients, not just physician-collected safety data and adverse events, are crucial to inform clinical decision-making on treatment options.

Item Type: Article
Keywords: castration-resistant prostate cancer, novel therapies, patient reported outcomes
Schools and Departments: Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C)
Subjects: R Medicine > R Medicine (General) > R852 Research. Experimentation > R853.C55 Clinical trials
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
R Medicine > RM Therapeutics. Pharmacology > RM0283 Endocrinotherapy. Organotherapy
Depositing User: Kathryn Monson
Date Deposited: 12 Jul 2016 11:27
Last Modified: 15 Mar 2017 03:23

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