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Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera

journal contribution
posted on 2023-06-09, 02:16 authored by Pat Simpson, Morag Lewis, Joanna Richardson
Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. Differences in the spatial expression of the proneural gene scute correlate with the positions of bristles in those species looked at so far. However, the examination of a number of genes encoding trans-regulatory factors, such as pannier, stripe, u-shaped, caupolican and wingless, indicates that they are expressed in conserved domains on the prospective notum. This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera, and that many differences are likely to be due to changes in cis-regulatory sequences of scute. In contrast, in Anopheles gambiae, a basal species with no stereotyped bristle pattern, the expression patterns of pannier and wingless are not conserved, and expression of AgASH, the Anopheles proneural gene, does not correlate in a similar manner with the bristle pattern. We discuss the possibility that independently acting cis-regulatory sequences at the scute locus may have arisen in the lineage giving rise to cyclorraphous flies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Development Genes and Evolution

ISSN

0949-944X

Publisher

Springer Verlag

Issue

7

Volume

216

Page range

363-371

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-07-27

First Compliant Deposit (FCD) Date

2016-07-27

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