Simpson, Pat, Lewis, Morag and Richardson, Joanna (2006) Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera. Development Genes and Evolution, 216 (7). pp. 363-371. ISSN 0949-944X

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Abstract

Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. Differences in the spatial expression of the proneural gene scute correlate with the positions of bristles in those species looked at so far. However, the examination of a number of genes encoding trans-regulatory factors, such as pannier, stripe, u-shaped, caupolican and wingless, indicates that they are expressed in conserved domains on the prospective notum. This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera, and that many differences are likely to be due to changes in cis-regulatory sequences of scute. In contrast, in Anopheles gambiae, a basal species with no stereotyped bristle pattern, the expression patterns of pannier and wingless are not conserved, and expression of AgASH, the Anopheles proneural gene, does not correlate in a similar manner with the bristle pattern. We discuss the possibility that independently acting cis-regulatory sequences at the scute locus may have arisen in the lineage giving rise to cyclorraphous flies.

Item Type:	Article
Keywords:	Calliphora, Bristle pattern, Scute, Cyclorraphous flies
Schools and Departments:	School of Life Sciences > Biochemistry
Subjects:	Q Science > QL Zoology > QL0951 Embryology
Depositing User:	Joanna Richardson
Date Deposited:	27 Jul 2016 15:39
Last Modified:	08 Mar 2017 04:57
URI:	http://srodev.sussex.ac.uk/id/eprint/62127

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