The roles of the exoribonucleases DIS3L2 and XRN1 in disease

Pashler, Amy L, Towler, Ben, Jones, Christopher I and Newbury, Sarah F (2016) The roles of the exoribonucleases DIS3L2 and XRN1 in disease. Biochemical Society Transactions, 44 (5). pp. 1377-1384. ISSN 0300-5127

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RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in development of multicellular organisms or human disease. This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible mechanisms and cellular pathways leading to these disease conditions.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Primary Care and Public Health
Subjects: Q Science > Q Science (General)
Depositing User: Sarah Newbury
Date Deposited: 05 Sep 2016 08:47
Last Modified: 20 Oct 2017 01:00

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