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Walker, Zuzana, Moreno, Emilio, Thomas, Alan, Inglis, Fraser, Tabet, Naji, Rainer, Michael, Pizzolato, Gilberto, Padovani, Alessandro and the DADE Investigator Group, et al. (2015) Clinical usefulness of dopamine transporter SPECT imaging with 123I-FP-CIT in patients with possible dementia with Lewy bodies: randomised study. British Journal of Psychiatry, 206 (2). pp. 145-152. ISSN 0007-1250
Full text not available from this repository.Abstract
BACKGROUND:
Dementia with Lewy bodies (DLB) is underrecognised in clinical settings.
AIMS:
To investigate whether performing a (123)I-ioflupane injection ((123)I-FP-CIT also called DaTSCAN™) single photon emission computed tomography (SPECT) scan in patients with possible DLB would lead to a more certain diagnosis (probable DLB or non-DLB dementia).
METHOD:
We randomised 187 patients with possible DLB 2:1 to have a scan or not (control group). The outcome measure was a change in diagnosis to probable DLB or non-DLB.
RESULTS:
There were 56 controls and 114 scanned patients, of whom 43% had an abnormal scan. More patients in the imaging group had a change in diagnosis compared with controls at 8 and 24 weeks (61% (n = 70) v. 4% (n = 2) and 71% (n = 77) v. 16% (n = 9); both P<0.0001). Clinicians were more likely to change the diagnosis if the scan was abnormal (82%) than if it was normal (46%).
CONCLUSIONS:
Imaging significantly contributed to a more certain diagnosis, proving to be a useful adjunct in the work-up of patients with possible DLB.
Royal College of Psychiatrists.
| Item Type: | Article |
|---|---|
| Keywords: | Dopamine, SPECT imagine 1231-FP-CIT, Randomised study |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience |
| Subjects: | R Medicine > R Medicine (General) > R852 Research. Experimentation R Medicine > R Medicine (General) > R852 Research. Experimentation > R853.C55 Clinical trials |
| Depositing User: | Linda Bennett |
| Date Deposited: | 13 Sep 2016 10:09 |
| Last Modified: | 18 Jul 2017 16:04 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/63269 |