Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Ismaili, Lhassane, Refouvelet, Bernard, Benchekroun, Mohamed, Brogi, Simone, Brindisi, Margherita, Gemma, Sandra, Campiani, Giuseppe, Filipic, Slavica, Agbaba, Danica, Esteban, Gerard, Unzeta, Mercedes, Nikolic, Katarina, Butini, Stefania and Marco-Contelles, José (2017) Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. Progress in Neurobiology, 151. pp. 4-34. ISSN 0301-0082

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Abstract

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Research Centres and Groups: Sussex Drug Discovery Centre
Subjects: R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0400 Pharmaceutical chemistry
Depositing User: Mohamed Benchekroun
Date Deposited: 25 Sep 2016 09:24
Last Modified: 27 Jun 2017 14:08
URI: http://srodev.sussex.ac.uk/id/eprint/63446
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