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Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
journal contribution
posted on 2023-06-09, 02:59 authored by Lhassane Ismaili, Bernard Refouvelet, Mohamed Benchekroun, Simone Brogi, Margherita Brindisi, Sandra Gemma, Giuseppe Campiani, Slavica Filipic, Danica Agbaba, Gerard Esteban, Mercedes Unzeta, Katarina Nikolic, Stefania Butini, José Marco-ContellesAlzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, ß-amyloid fibril deposition, and ß-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and ß-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as ß-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.
History
Publication status
- Published
Journal
Progress in NeurobiologyISSN
0301-0082Publisher
ElsevierExternal DOI
Volume
151Page range
4-34Department affiliated with
- Chemistry Publications
Research groups affiliated with
- Sussex Drug Discovery Centre Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-09-25Usage metrics
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