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Mapping the altered patterns of cerebellar resting-state function in longitudinal amnestic mild cognitive impairment patients
journal contribution
posted on 2023-06-09, 03:03 authored by Feng Baia, Wei Liaoc, David R Watson, Yongmei Shib, Yonggui Yuanb, Alexander D Cohene, Chunming Xiea, Yi Wanga, Chunxian Yuea, Yuhuan Tenga, Di Wua, Jianping JiafThe cerebellum is known to be a relatively well preserved structure, but subtle alterations may occur early in the evolution of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) patients appear to be particularly vulnerable to AD. However, little is currently known whether altered patterns of cerebellar function occur in aMCI patients. 26 aMCI patients and 18 well-matched healthy controls underwent a baseline resting-state functional magnetic resonance imaging (fMRI) scan. After a mean follow-up period of 20 months, the subjects who successfully completed baseline fMRI scans underwent a further follow-up scan, while spontaneous activation and functional connectivity of the cerebellum were explored by using resting-state fMRI. Compared to controls, increased amplitude of low frequency fluctuation of the posterior cerebellar lobe may contribute to the underlying mechanisms affected, while greater decreased functional connections to the posterior cerebellar lobe were identified in the longitudinal study of aMCI patients. This suggests that abnormal functional connectivity of the cerebellum may offer a more sensitive and possibly preferred index of functional disturbance than regional activity measures in aMCI patients. The cerebellum may be partly related to the underlying mechanisms of aMCI, and it could help guide subsequent investigations designed to specify the precise functional role of cerebellum in aMCI patients.
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Publication status
- Published
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- Published version
Journal
Journal of Alzheimer's DiseaseISSN
1387-2877Publisher
IOS PressExternal DOI
Issue
1Volume
23Page range
87-99Department affiliated with
- BSMS Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-10-03First Compliant Deposit (FCD) Date
2016-10-03Usage metrics
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