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The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

journal contribution
posted on 2023-06-09, 03:26 authored by Ali Nokhodchi, H Nazemiyeh, Taravat Ghafourian, D Hassan-Zadeh, H Valizadeh, L A S Bahary
The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1 w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. © 2002 �ditions scientifiques et médicales Elsevier SAS. All rights reserved.

History

Publication status

  • Published

Journal

Farmaco

ISSN

0014-827X

Publisher

Elsevier

Issue

11

Volume

57

Page range

883-888

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-11-29