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DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA
journal contribution
posted on 2023-06-09, 04:04 authored by J James, D Castellano, Adam Eyre-WalkerAdam Eyre-WalkerSelection is expected to be more efficient in species that are more diverse because both the efficiency of natural selection and DNA sequence diversity are expected to depend upon the effective population size. We explore this relationship across a data set of 751 mammal species for which we have mitochondrial polymorphism data. We introduce a method by which we can examine the relationship between our measure of the efficiency of natural selection, the nonsynonymous relative to the synonymous nucleotide site diversity (pN/pS), and synonymous nucleotide diversity (pS), avoiding the statistical non-independence between the two quantities. We show that these two variables are strongly negatively and linearly correlated on a log scale. The slope is such that as pS doubles, pN/pS is reduced by 34%. We show that the slope of this relationship differs between the two phylogenetic groups for which we have the most data, rodents and bats, and that it also differs between species with high and low body mass, and between those with high and low mass-specific metabolic rate.
History
Publication status
- Published
File Version
- Accepted version
Journal
HeredityISSN
0018-067XPublisher
Nature Publishing GroupExternal DOI
Issue
118Volume
2017Page range
88-95Department affiliated with
- Evolution, Behaviour and Environment Publications
Research groups affiliated with
- Centre for Byzantine Cultural History Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-11-16First Open Access (FOA) Date
2017-05-10First Compliant Deposit (FCD) Date
2016-11-16Usage metrics
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