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Nokhodchi et al., 2016.pdf (1.31 MB)

The use of various organic solvents to tailor the properties of Ibuprofen-glucosamine HCl solid dispersions

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posted on 2023-06-09, 04:05 authored by Ali Nokhodchi, Hiba Al-Hamidi, Adeola O Adebisi, Kofi Asare-Addo, Mohammed Maniruzzaman
A fast release dosage form is desirable to improve the absorption of poorly water soluble drugs. Ibuprofen (IBU) is a BCS class II drug that exhibits poor dissolution rate in the gastrointestinal (GI) tract. The aim of the present study is to use various organic solvents to prepare solid dispersions of IBU in the presence of glucosamine HCl (GL), which acts as a carrier to enhance the dissolution of ibuprofen. Different ratios of ibuprofen and glucosamine were dissolved in various organic solvents to obtain the solid dispersions of ibuprofen-glucosamine mixtures. The physic-chemical/solid state analysis of the samples investigated using SEM, DSC, FT-IR and XRPD, particle size analysis and in vitro dissolution studies showed that the type of solvent has a big influence on the dissolution. Ibuprofen-glucosamine solid dispersions obtained from acetone produced better dissolution compared to that of other organic solvents. The effect of water in binary mixtures of acetone or ethanol was also investigated and the results showed that when the ratio of acetone to water was 75:25, the highest dissolution was obtained. Solid state analysis ruled out any chemical interaction between the dug and carrier even in the presence of various organic solvents which indicates a good stability of the solid dispersions to enhance the dissolution rate of ibuprofen. It was also investigated via XRPD analysis that the ibuprofen retained its crystallinity without any adverse effect on the dissolution rates.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Chemical Engineering Research and Design

ISSN

0263-8762

Publisher

Elsevier

Volume

117

Page range

509-519

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-11-18

First Open Access (FOA) Date

2017-11-19

First Compliant Deposit (FCD) Date

2016-11-18

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