Time-delayed model of RNA interference

Neofytou, G, Kyrychko, Y N and Blyuss, K B (2017) Time-delayed model of RNA interference. Ecological Complexity, 30. pp. 11-25. ISSN 1476-945X

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RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis. In this paper we consider a mathematical model of RNAi with particular emphasis on time delays associated with two aspects of primed amplification: binding of siRNA to aberrant RNA, and binding of siRNA to mRNA, both of which result in the expanded production of dsRNA responsible for RNA silencing. Analytical and numerical stability analyses are performed to identify regions of stability of different steady states and to determine conditions on parameters that lead to instability. Our results suggest that while the original model without time delays exhibits a bi-stability due to the presence of a hysteresis loop, under the influence of time delays, one of the two steady states with the high (default) or small (silenced) concentration of mRNA can actually lose its stability via a Hopf bifurcation. This leads to the co-existence of a stable steady state and a stable periodic orbit, which has a profound effect on the dynamics of the system.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Research Centres and Groups: Mathematics Applied to Biology Research Group
Subjects: Q Science > QA Mathematics
Depositing User: Konstantin Blyuss
Date Deposited: 06 Jan 2017 12:04
Last Modified: 06 Jan 2018 02:00
URI: http://srodev.sussex.ac.uk/id/eprint/65821

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