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Network functional connectivity and whole-brain functional connectomics to investigate cognitive decline in neurodegenerative conditions

journal contribution
posted on 2023-06-09, 04:30 authored by Ottavia Dipasqualie, Mara Cercignani
Non-invasive mapping of brain functional connectivity (FC) has played a fundamental role in neuroscience, and numerous scientists have been fascinated by its ability to reveal the brain's intricate morphology and functional properties. In recent years, two different techniques have been developed that are able to explore FC in pathophysiological conditions and to provide simple and non-invasive biomarkers for the detection of disease onset, severity and progression. These techniques are independent component analysis, which allows a network-based functional exploration of the brain, and graph theory, which provides a quantitative characterization of the whole-brain FC. In this paper we provide an overview of these two techniques and some examples of their clinical applications in the most common neurodegenerative disorders associated with cognitive decline, including mild cognitive impairment, Alzheimer's disease, Parkinson's disease, dementia with Lewy Bodies and behavioral variant frontotemporal dementia

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Functional Neurology

ISSN

0393-5264

Publisher

CIC Edizioni Internazionali

Issue

4

Volume

31

Page range

191-203

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-03

First Compliant Deposit (FCD) Date

2017-01-03

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