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Network functional connectivity and whole-brain functional connectomics to investigate cognitive decline in neurodegenerative conditions
journal contribution
posted on 2023-06-09, 04:30 authored by Ottavia Dipasqualie, Mara CercignaniNon-invasive mapping of brain functional connectivity (FC) has played a fundamental role in neuroscience, and numerous scientists have been fascinated by its ability to reveal the brain's intricate morphology and functional properties. In recent years, two different techniques have been developed that are able to explore FC in pathophysiological conditions and to provide simple and non-invasive biomarkers for the detection of disease onset, severity and progression. These techniques are independent component analysis, which allows a network-based functional exploration of the brain, and graph theory, which provides a quantitative characterization of the whole-brain FC. In this paper we provide an overview of these two techniques and some examples of their clinical applications in the most common neurodegenerative disorders associated with cognitive decline, including mild cognitive impairment, Alzheimer's disease, Parkinson's disease, dementia with Lewy Bodies and behavioral variant frontotemporal dementia
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Publication status
- Published
File Version
- Accepted version
Journal
Functional NeurologyISSN
0393-5264Publisher
CIC Edizioni InternazionaliExternal DOI
Issue
4Volume
31Page range
191-203Department affiliated with
- BSMS Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-01-03First Compliant Deposit (FCD) Date
2017-01-03Usage metrics
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