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Shunt peaking in neural membranes

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posted on 2023-06-09, 04:35 authored by Francisco J H Heras, Simon B Laughlin, Jeremy NivenJeremy Niven
Capacitance limits the bandwidth of engineered and biological electrical circuits because it determines the gain–bandwidth product (GBWP). With a fixed GBWP, bandwidth can only be improved by decreasing gain. In engineered circuits, an inductance reduces this limitation through shunt peaking but no equivalent mechanism has been reported for biological circuits. We show that in blowfly photoreceptors a voltage-dependent K+ conductance, the fast delayed rectifier (FDR), produces shunt peaking thereby increasing bandwidth without reducing gain. Furthermore, the FDR's time constant is close to the value that maximizes the photoreceptor GBWP while reducing distortion associated with the creation of a wide-band filter. Using a model of the honeybee drone photoreceptor, we also show that a voltage-dependent Na+ conductance can produce shunt peaking. We argue that shunt peaking may be widespread in graded neurons and dendrites.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Interface

ISSN

1742-5662

Publisher

The Royal Society

Issue

124

Volume

13

Department affiliated with

  • Evolution, Behaviour and Environment Publications

Research groups affiliated with

  • Centre for Computational Neuroscience and Robotics Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-06

First Open Access (FOA) Date

2017-11-03

First Compliant Deposit (FCD) Date

2017-01-06

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