Shunt peaking in neural membranes.pdf (799.36 kB)
Shunt peaking in neural membranes
journal contribution
posted on 2023-06-09, 04:35 authored by Francisco J H Heras, Simon B Laughlin, Jeremy NivenJeremy NivenCapacitance limits the bandwidth of engineered and biological electrical circuits because it determines the gain–bandwidth product (GBWP). With a fixed GBWP, bandwidth can only be improved by decreasing gain. In engineered circuits, an inductance reduces this limitation through shunt peaking but no equivalent mechanism has been reported for biological circuits. We show that in blowfly photoreceptors a voltage-dependent K+ conductance, the fast delayed rectifier (FDR), produces shunt peaking thereby increasing bandwidth without reducing gain. Furthermore, the FDR's time constant is close to the value that maximizes the photoreceptor GBWP while reducing distortion associated with the creation of a wide-band filter. Using a model of the honeybee drone photoreceptor, we also show that a voltage-dependent Na+ conductance can produce shunt peaking. We argue that shunt peaking may be widespread in graded neurons and dendrites.
History
Publication status
- Published
File Version
- Accepted version
Journal
InterfaceISSN
1742-5662Publisher
The Royal SocietyExternal DOI
Issue
124Volume
13Department affiliated with
- Evolution, Behaviour and Environment Publications
Research groups affiliated with
- Centre for Computational Neuroscience and Robotics Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-01-06First Open Access (FOA) Date
2017-11-03First Compliant Deposit (FCD) Date
2017-01-06Usage metrics
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