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New peptides under the s(ORF)ace of the genome

journal contribution
posted on 2023-06-09, 04:40 authored by Jose Pueyo-Marques, Emile G Magny, Juan Pablo Couso
Hundreds of previously unidentified functional small peptides could exist in most genomes, but these sequences have been generally overlooked. The discovery of genes encoding small peptides with important functions in different organisms, has ignited the interest in these sequences, and led to an increasing amount of effort towards their identification. Here, we review the advances, both, computational, and biochemical, that are leading the way in the discovery of putatively functional smORFs, as well as the functional studies that have been carried out as a consequence of these searches. The evidence suggests that smORFs form a substantial part of our genomes, and that their encoded peptides could have important functions in a variety of cellular functions

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Trends in Biochemical Sciences

ISSN

0968-0004

Publisher

Elsevier

Issue

8

Volume

41

Page range

665-678

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-01-12

First Open Access (FOA) Date

2017-06-01

First Compliant Deposit (FCD) Date

2017-01-12

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